Drosophila Sensation U01

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    National Institutes of HealthStarted August 2024
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    Supported by the National Institutes of Health U01 program, we assist researchers studying sensory processing in Drosophila to standardize their data using the NWB format. This project involves five labs (Cohen, Dickerson, Fox, Kim, and Suver) that use diverse experimental approaches including electrophysiology, calcium imaging, and behavioral tracking. By creating standardized data pipelines, this initiative facilitates cross-lab collaboration and integrated analysis of sensory processing in the fly nervous system.

    Affiliated NWB Conversions

    Jessica Fox

    Case Western Reserve University

    2024

    Developed NWB conversion tools for the Fox lab's research on Drosophila sensory systems. The pipeline standardizes high-speed video recordings, DeepLabCut output files, confocal imaging data, and intracellular electrophysiology recordings. These tools integrate stimulus traces and synchronization signals from Spike2, enabling researchers to study sensory processing across multiple modalities with precisely aligned data.

    Itai Cohen

    Cornell University

    2024

    Developed NWB conversion tools for the Cohen lab's research on Drosophila behavior. The conversion pipeline standardizes high-resolution videos of behaving flies along with synchronized behavioral measurements stored in MATLAB formats. These tools enable researchers to correlate detailed fly movements with other physiological and sensory data.

    Bradley Dickerson

    Princeton University

    2024

    Developed NWB conversion tools for the Dickerson lab's research on Drosophila sensory processing. The pipeline standardizes two-photon imaging data from ThorLabs microscopes, neck muscle imaging, and high-speed video recordings. These tools integrate synchronization data from ThorSync to align neural and behavioral measurements, facilitating comprehensive analysis of sensory-motor transformations.

    Sung Soo Kim

    UC Santa Barbara

    2024

    Developed NWB conversion tools for the Kim lab's research on Drosophila visual processing. The pipeline standardizes two-photon imaging data, behavioral videos, and visual stimulus information. These tools integrate synchronization signals from MATLAB files and fluorescence traces from segmented regions of interest, facilitating analysis of neural responses to visual stimuli in relation to behavioral outputs.

    Marie Suver

    Vanderbilt University

    2024

    Developed NWB conversion tools for the Suver lab's research on Drosophila sensorimotor integration. The pipeline standardizes behavioral data from multiple cameras, wing beat tracking from microphone or tachometer recordings, antenna position tracking via DeepLabCut, and patch clamp recordings through Nidaq. These tools enable comprehensive analysis of neural activity in relation to complex fly behaviors.